Hydrochloric Acid → HCID 67505771, Verbindung

HRID 881897Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 881897
[CH2:1]([O:3][C:4](=[O:31])[C@@H:5]([CH3:30])[CH2:6][CH:7]([NH:22]C(OC(C)(C)C)=O)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:2].Cl>C(Cl)Cl>[ClH:21].[CH2:1]([O:3][C:4](=[O:31])[C@@H:5]([CH3:30])[CH2:6][CH:7]([NH2:22])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67505776(S)-4-tert-butoxycarbonylamino-5-(3'-chloro-biphenyl-4-yl)-2-methyl-pentanoic acid ethyl ester

Produkt 1

HCID 67505771HCID 67505771, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Next, to a solution of (S)-4-tert-butoxycarbonylamino-5-(3′-chloro-biphenyl-4-yl)-2-methyl-pentanoic acid ethyl ester (2.47 g, 5.54 mmol) in DCM (15 mL) is added 5 mL of HCl (4N in dioxane) and the mixture is stirred at room temperature for 2 hours. The solvent is removed under reduced pressure to afford the title compound; HPLC Retention time 1.48 minutes (condition A): MS 346.2 (M+1).

Aufarbeitung

  1. customThe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-71db50fa600440a18033cc2271537b31
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993631B2

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