4-((5-Fluoropyridin-2-yl)methoxy)pyridin-2(1H)-one → tert-Butyl 7,9-dimethyl-2-(4-((5-fluoropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate

HRID 882051Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 882051
Br[C:2]1[N:7]=[C:6]2[N:8]([CH3:23])[C:9]3[CH2:14][CH:13]([CH3:15])[N:12]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:11][C:10]=3[C:5]2=[CH:4][CH:3]=1.[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][NH:36][C:35](=[O:39])[CH:34]=2)=[N:29][CH:30]=1>>[CH3:15][CH:13]1[N:12]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:11][C:10]2[C:5]3[C:6]([N:8]([CH3:23])[C:9]=2[CH2:14]1)=[N:7][C:2]([N:36]1[CH:37]=[CH:38][C:33]([O:32][CH2:31][C:28]2[CH:27]=[CH:26][C:25]([F:24])=[CH:30][N:29]=2)=[CH:34][C:35]1=[O:39])=[CH:3][CH:4]=3

Komponenten

3

Edukt 2

HCID 579503414-((5-Fluoropyridin-2-yl)methoxy)pyridin-2(1H)-oneHCID 86667082tert-Butyl 2-bromo-7,9-dimethyl-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylate

Produkt 1

HCID 67988844tert-Butyl 7,9-dimethyl-2-(4-((5-fluoropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-5,7,8,9-tetrahydro-6H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-6-carboxylateAusbeute 73,3 %

Versuchsvorschrift

tert-Butyl 2-bromo-7,9-dimethyl-5,7,8,9-tetrahydro-6H-pyrido[3′,4′:4,5]pyrrolo[2,3-b]pyridine-6-carboxylate (200 mg, 0.520 mmol) and 4-((5-fluoropyridin-2-yl)methoxy)pyridin-2(1H)-one (115 mg, 0.520 mmol) were reacted following the procedure for Example 2 (step e) to provide the title compound (198 mg, 73%) as a yellow oil: ESI MS m/z 520 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-f1d110ce92ad418e9b84cebd237f9301
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993765B2

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