Diisopropylethylamine → 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	1-(3,4-Dichlorophenyl)piperazine	HCID 93601	—
Edukt	Sodium triacetoxyborohydride	HCID 5049666	—
Edukt	3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal	HCID 86639925	—
Produkt	1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(3,4-dichlorophenyl)piperazine	HCID 25064848	—

Reaktionsschritte

92 mg (94%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal (50 mg, 0.191 mmol), 1-(3,4-dichlorophenyl)piperazine (44 mg, 0.191 mmol), DIPEA (0.050 mL, 0.287 mmol) and NaBH(OAc)3 (121 mg, 0.573 mmol).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08236806B2
Quelldatensatz	uspto-grants-2012_08
ORD ID	ord-b4aa5fc6cf4946cba336351f09d8589c
Quellennotiz	uspto-grants-2012_08