Potassium Cyanide → methyl cyano[3-cyano-2-oxo-5-(trifluoromethoxy)-2,3-dihydro-1H-indol-3-yl]acetate

HRID 883644

Reaktionsgleichung

Reaktionsgleichung von HRID 883644
[C:1](/[C:3](=[C:8]1/[C:9](=[O:22])[NH:10][C:11]2[C:16]/1=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)/[C:4]([O:6][CH3:7])=[O:5])#[N:2].[C-:23]#[N:24].[K+]>>[C:1]([CH:3]([C:8]1([C:23]#[N:24])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([F:19])([F:21])[F:20])[CH:15]=2)[NH:10][C:9]1=[O:22])[C:4]([O:6][CH3:7])=[O:5])#[N:2]

Komponenten

3

Edukt 2

HCID 9032Potassium CyanideHCID 67424559methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate2×

Produkt 1

HCID 67425381methyl cyano[3-cyano-2-oxo-5-(trifluoromethoxy)-2,3-dihydro-1H-indol-3-yl]acetateAusbeute 90 %

Versuchsvorschrift

Following the general method as outlined for Intermediate 5, starting from methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate (intermediate 3) and potassium cyanide, the title compound was isolated, after evaporation, as a pale brown solid in 90% yield. This was a mixture of diastereomers.

Quellen und Nachweise

ORD-Eintrag
ord-f3d4a8b30f0a4d6894bd12c0f1f01b3b
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236963B2

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