2-Methoxyethylamine → 4-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide

HRID 883898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 883898
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][O:22][CH2:23][CH2:24][NH2:25]>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:25][CH2:24][CH2:23][O:22][CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

Komponenten

4

Edukt 2

HCID 80182-MethoxyethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

Produkt 1

HCID 259313144-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound from Example 34c (1.0 g, 3.2 mmol) in CH2Cl, was added to a mixture of 2-methoxyethanamine (722 mg, 9.61 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving the title compound as a yellow oil (1.1 g, 100%).

Aufarbeitung

  1. concentrationMixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0eb19f933332488b99aa77dee45322bd
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236950B2

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