N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol

HRID 883931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 883931
[NH2:1][C:2]1[CH:3]=[C:4]([OH:16])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.C([C:19]1[C:20]([N:25]=[CH:26][N:27]([CH3:29])C)=[N:21][CH:22]=[CH:23][CH:24]=1)#N.NC1C=C(OCC2C=CC=C(F)C=2)C=CC=1SC1C=CC(O)=CC=1>>[OH:15][C:12]1[CH:13]=[CH:14][C:9]([S:8][C:7]2[CH:6]=[CH:5][C:4]([OH:16])=[CH:3][C:2]=2[NH:1][C:29]2[C:19]3[CH:24]=[CH:23][CH:22]=[N:21][C:20]=3[N:25]=[CH:26][N:27]=2)=[CH:10][CH:11]=1

Komponenten

4

Edukt 3

HCID 66808319N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidineHCID 668086774-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenolHCID 670403013-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol2×

Produkt 1

HCID 670407844-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenolAusbeute 35,4 %

Versuchsvorschrift

The product of Example 48B (380 mg, 1.63 mmol) was reacted with the product of Example 15A (284 mg, 1.63 mmol) using the procedure of Example 15E substituting the product of Example 48B for the product of Example 15D to provide a solid which was triturated with methanol to provide the title compound (209 mg, 35%).

Aufarbeitung

  1. customto provide a solid which
  2. customwas triturated with methanol

Quellen und Nachweise

ORD-Eintrag
ord-48658e87e4e14f8a8d5f6ec4b419f02c
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236950B2

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