Triethylamine → Methyl 5-(2,2-difluoroethoxy)-2-nitrobenzoate

HRID 884494

Reaktionsgleichung

Reaktionsgleichung von HRID 884494
[F:1][CH:2]([F:5])[CH2:3][OH:4].F[C:7]1[CH:8]=[CH:9][C:10]([N+:17]([O-:19])=[O:18])=[C:11]([CH:16]=1)[C:12]([O:14][CH3:15])=[O:13].CCN(CC)CC.C(N1CCN2CCN(CC(C)C)P1N(CC(C)C)CC2)C(C)C>C1COCC1>[F:1][CH:2]([F:5])[CH2:3][O:4][C:7]1[CH:8]=[CH:9][C:10]([N+:17]([O-:19])=[O:18])=[C:11]([CH:16]=1)[C:12]([O:14][CH3:15])=[O:13]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 1361872,2-Difluoroethan-1-olHCID 45712432,8,9-Triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo(3.3.3)undecaneHCID 51520495-Fluoro-2-nitrobenzoic acid methyl ester

Produkt 1

HCID 59587324Methyl 5-(2,2-difluoroethoxy)-2-nitrobenzoateAusbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

8.53 g of 2,2-difluoroethanol are added to a solution of 17.31 g of methyl 5-fluoro-2-nitrobenzoate, 9.64 g of NEt3 and 32.71 g of 2,8,9-triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane in 250 ml of anhydrous THF. The mixture is stirred at AT for 30 min. The solvent is evaporated under reduced pressure. Water is added and extraction is carried out with AcOEt. The extract is washed with a 1N aqueous HCl solution, with water and then with a saturated NaCl solution. It is dried over MgSO4 and filtered, and the solvent is evaporated under reduced pressure to give 21 g of the expected product.

Aufarbeitung

  1. customThe solvent is evaporated under reduced pressure
  2. additionWater is added
  3. extractionextraction
  4. washThe extract is washed with a 1N aqueous HCl solution, with water
  5. dry with materialIt is dried over MgSO4
  6. filtrationfiltered
  7. customthe solvent is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1678e75005d04bed986816e25f7c3ac4
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242126B2

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