Hydrochloric Acid → (2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester

HRID 885267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 885267
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=[O:11].Cl.[CH3:14]O>>[CH3:14][O:11][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([OH:8])[CH:6]=[CH:7][C:2]=1[Br:1]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 572578212-(2-Bromo-5-hydroxyphenyl)acetic acid

Produkt 1

HCID 58237580(2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To (2-bromo-5-hydroxy-phenyl)-acetic acid (1.5 g, 6.5 mmol) in MeOH (15 mL) was added HCl (4N in 1,4-dioxane; 3 mL), and the solution was heated to 70° C. for 8 hours. The mixture was concentrated to give the desired product as a white solid (1.2 g).

Aufarbeitung

  1. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ae8102e6250c4aa39cf8a1804d19e967
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242145B2

Notizen zur Reaktion

Wird geladen…