(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester → (2-Chloro-5-hydroxy-phenyl)-acetic acid ethyl ester

HRID 885287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 885287
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]

Komponenten

3

Edukt 1

HCID 58148945(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester

Produkt 1

HCID 57966617(2-Chloro-5-hydroxy-phenyl)-acetic acid ethyl esterAusbeute 83,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give the desired product (1 g).

Aufarbeitung

  1. customdegassed with N2
  2. addition5% Palladium on carbon (1 g) was added
  3. customthe reaction was purged with H2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4b6961fbbb7644289ea766ff558c8fa6
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242145B2

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