2-Pyrrolidone → {3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

HRID 885411

Reaktionsgleichung

Reaktionsgleichung von HRID 885411
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20]Br)[CH:7]=1)[CH3:2].[NH:23]1[CH2:27][CH2:26][CH2:25][C:24]1=[O:28].[H-].[Na+]>O1CCOCC1>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20][N:23]2[CH2:27][CH2:26][CH2:25][C:24]2=[O:28])[CH:7]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 120252-PyrrolidoneHCID 24758Sodium hydrideHCID 58237602[3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester

Produkt 1

HCID 67105918{3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

[3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.15 g, 0.35 mmol) and 2-pyrrolidinone (0.05 g, 0.53 mmol) were combined in 1,4-dioxane (10 mL). Sodium hydride (60% in mineral oil; 0.03 g, 0.7 mmol) was added, and the reaction was stirred at room temperature for 2 hours to give the title compound, which was used as a crude solution in the hydrolysis step.

Quellen und Nachweise

ORD-Eintrag
ord-036d42e1c7a54062941b388336509174
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242145B2

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