(Z)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrile → HCID 178437439, Verbindung

HRID 885441

Reaktionsgleichung

Reaktionsgleichung von HRID 885441
[CH2:1]([C:3]1[N:13](CC2C=CC3/C(=C(/C)\C#N)/C4C=CC=CC=4CCC=3C=2)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].OCC1C=CC2/C(=C(/C)\C#N)/C3C=CC=CC=3CCC=2C=1>>[CH2:1]([C:3]1[NH:13][C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 67210308(Z)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrileHCID 69018523(Z)-2-[2-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]propiononitrile

Produkt 1

HCID 178437439HCID 178437439, VerbindungAusbeute 230,1 %

Versuchsvorschrift

[step 1] (Z)-2-[2-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]propiononitrile (376 mg, 68%) was obtained in the same manner as in step 1 of Example 36, using (Z)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrile (350 mg, 1.3 mmol) obtained in Reference Example 6 and 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (349 mg, 2.0 mmol) instead of 5-chloro-2-ethyl-7-methyl-3H-imidazo[4,5-b]pyridine.

Quellen und Nachweise

ORD-Eintrag
ord-a977f7ef3f4544a393334aa25bf440ca
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242151B2

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