2-(3-Bromophenyl)-2,2-difluoroethanol → 1-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

HRID 885547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 885547
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([F:12])([F:11])[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]OCC(F)(F)CCC1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:12])[CH2:9][O:10][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][Br:13])[CH:3]=1

Komponenten

3

Edukt 2

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanolHCID 67246468{4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene

Produkt 1

HCID 672452111-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

Versuchsvorschrift

Obtained from Intermediate 49 (17.6 g, 74 mmol) by the procedure described in Intermediate 3. The crude oil was purified by distillation to yield the title compound as oil of 60% of purity (9.5 g). The distillation residue was purified by column chromatography with silica gel and methylene chloride as eluent to yield a second batch of 1-bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene of 65% of purity (15.2 g) (overall yield: 53%).

Aufarbeitung

  1. distillationThe crude oil was purified by distillation

Quellen und Nachweise

ORD-Eintrag
ord-f30c18b5f0e9438ea101a29d20588bd2
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242177B2

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