Ammonia → 4-Bromo-2-fluorobenzimidamide hydrochloride

HRID 886197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 886197
[ClH:1].C(O[C:5](=[NH:14])[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:7]=1[F:13])C.[NH3:15]>>[ClH:1].[Br:12][C:9]1[CH:10]=[CH:11][C:6]([C:5]([NH2:14])=[NH:15])=[C:7]([F:13])[CH:8]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 670507354-Bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride

Produkt 1

HCID 534078914-Bromo-2-fluorobenzimidamide hydrochlorideAusbeute 100 %

Versuchsvorschrift

A mixture of 4-bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride (20.3 g, 72 mmol) in IMS (250 mL) at 0-5° C. was saturated with NH3 (gas), and the flask sealed before allowing to warm to RT and stirring for 18 h. Solvent was removed in vacuo and the residue triturated in diethyl ether to give 4-Bromo-2-fluoro-benzamidine hydrochloride as a white solid (18.1 g, 100%). 1H NMR δ (ppm) (DMSO-d): 9.26 (4H, s), 7.92-7.87 (1H, m), 7.71-7.62 (2H, m).

Aufarbeitung

  1. customthe flask sealed
  2. customSolvent was removed in vacuo
  3. customthe residue triturated in diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-0bdf762eda654712a75cb136a6ea9fc2
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08242104B2

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