2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol → 1,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-

HRID 886695Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 886695
[F:1][C:2]([F:17])([F:16])[C:3]([CH2:7][NH:8]CC1C=CC=CC=1)([OH:6])[CH2:4][OH:5]>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:8][CH2:7][C:3]([OH:6])([C:2]([F:17])([F:16])[F:1])[CH2:4][OH:5]

Komponenten

4

Edukt 1

HCID 248097812-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol

Produkt 1

HCID 248097501,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-Ausbeute 95,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3,3,3-trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (8.33 g, 33.4 mmol) in ethanol (550 ml) containing palladium hydroxide on carbon (20%, 800 mg) was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered off via a pad of celite and the filtrate was concentrated under reduced pressure, toluene was added and the solution evaporated again under reduced pressure to give the title compound (5.06 g) as an oil.

Aufarbeitung

  1. filtrationThe catalyst was filtered off via a pad of celite
  2. concentrationthe filtrate was concentrated under reduced pressure, toluene
  3. additionwas added
  4. customthe solution evaporated again under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c42b2b1722744161942cd27dc0535e31
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247377B2

Notizen zur Reaktion

Wird geladen…