[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol → 4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde

HRID 886787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 886787
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 57606985[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol

Produkt 1

HCID 576069534-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehydeAusbeute 93,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysator2×HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of [4-(ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol (41.0 g) in chloroform (4000 mL) was added manganese oxide (125 g, 1.4 mole) and stirred for 4 h at room temperature. More manganese oxide was added until the disappearance of alcohol compound was observed. The reaction mixture was filtered through Celite and washed with some chloroform and evaporated all organic solvents to give 38 g (92% yield) of 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde as a colorless solid, which was used without purification in the next step.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with some chloroform
  3. customevaporated all organic solvents

Quellen und Nachweise

ORD-Eintrag
ord-be2788b1b3cd44279d34e48ce3ada367
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247408B2

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