Hydrogen chloride-ethyl acetate → HCID 68578424, Verbindung
Reaktionsgleichung
[N:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:31]>>[ClH:31].[ClH:31].[N:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Komponenten
3
Versuchsvorschrift
A solution of tert-butyl 8-(piperidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (280 mg, 0.843 mmol) in 4N hydrogen chloride-ethyl acetate (6 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (210 mg, 81.7%) as a solid.
Aufarbeitung
- customthe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from a mixed solvent of methanol and ether