Hydrogen chloride-ethyl acetate → HCID 68578005, Verbindung
Reaktionsgleichung
[CH2:1]([N:3]([CH2:22][CH3:23])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:2].C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[CH2:22]([N:3]([CH2:1][CH3:2])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][NH:9][CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:23]Komponenten
3
Versuchsvorschrift
A solution of tert-butyl 8-(diethylamino)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (250 mg, 0.780 mmol) in 4N hydrogen chloride-ethyl acetate (6 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (144 mg, 62.9%) as a solid.
Aufarbeitung
- customthe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from a mixed solvent of methanol and ether