1H-Indazol-4-amine, 1-methyl- → N-[4-(1-azepanyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)urea

HRID 887236

Reaktionsgleichung

Reaktionsgleichung von HRID 887236
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[C:2]=[O:3].[CH3:18][N:19]1[C:27]2[CH:26]=[CH:25][CH:24]=[C:23]([NH2:28])[C:22]=2[CH:21]=[N:20]1.N1C2C=CC=C(N)C=2C=N1>>[N:11]1([C:8]2[CH:9]=[CH:10][C:5]([CH2:4][NH:1][C:2]([NH:28][C:23]3[CH:24]=[CH:25][CH:26]=[C:27]4[C:22]=3[CH:21]=[N:20][N:19]4[CH3:18])=[O:3])=[CH:6][CH:7]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

4

Edukt 3

HCID 1538381H-Indazol-4-amine, 1-methyl-HCID 413085NoName_3327HCID 223377021-[4-(Isocyanatomethyl)phenyl]azepane

Produkt 1

HCID 22337694N-[4-(1-azepanyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)urea

Versuchsvorschrift

The title compound was prepared using the procedure described in Example 89B using 1-[4-(isocyanatomethyl)phenyl]azepane and 1-methyl-1H-indazol-4-amine instead of 1-bromo-4-(isocyanatomethyl)benzene and the product from Example 89A. NMR (DMSO-d6) δ 8.97 (s, 1H), 8.18 (s, 1H), 7.65 (d, 1H), 7.14 (m, 4H), 7.11 (d, 1H), 6.95 (bs, 2H), 4.23 (s, 2H), 3.99 (s, 3H), 3.27 (m, 4H), 1.90 (m, 4H), 1.53 (m, 4H); MS (ESI) (M+H)+ 378.

Quellen und Nachweise

ORD-Eintrag
ord-bba02886e2a14fc88302edf1da24b4b1
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247413B2

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