Trifluoroacetic acid → 4-(Aminomethyl)benzonitrile

HRID 887261

Reaktionsgleichung

Reaktionsgleichung von HRID 887261
C(OC([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=1)C(OC(C)(C)C)=O)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:24][CH2:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]#[N:8])=[CH:18][CH:19]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 3683768Tert-butyl N-[(4-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Produkt 1

HCID 826084-(Aminomethyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of N,N-bis(tert-butoxycarbonyl)-4-cyanobenzylamine (0.75 g, 2.25 mmol, prepared according to the literature described in Synthetic Communications 4419:28 (1998), in CH2Cl2 (15 mL) was treated with trifluoroacetic acid (8 mL). After stirring at room temperature for 3 hours, the mixture was concentrated under reduced pressure and the residue was azeotroped with diethyl ether.

Aufarbeitung

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customthe residue was azeotroped with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-25d9167931af4b95b23a56ba7ae42a65
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247413B2

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