2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine → 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

HRID 887456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 887456
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:12]([F:13])=[N:11][CH:10]=[CH:9][N:8]=2)[CH2:3][CH2:2]1>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[F:13][C:12]1[C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][CH:9]=[CH:10][N:11]=1

Komponenten

4

Edukt 1

HCID 593511782-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine

Produkt 1

HCID 593512282-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a round bottomed flask was added 2-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine (1.1754 g, 6.52 mmol) and palladium hydroxide on carbon (0.458 g, 0.652 mmol) in EtOAc (21.75 mL). The round bottomed flask was flushed with argon and then placed under vacuum three times. A hydrogen balloon was then attached to the reaction. After stirring overnight, the reaction was filtered through celite to provide 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine. [M+H]=183.1.

Aufarbeitung

  1. customThe round bottomed flask was flushed with argon
  2. customA hydrogen balloon was then attached to the reaction
  3. filtrationthe reaction was filtered through celite

Quellen und Nachweise

ORD-Eintrag
ord-48db84fece684ccbb05fcbab8cfa944a
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247418B2

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