Ammonia methanol → 2-(5-chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethanamine

(5-Chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile (116 mg, 2.87 mmol) was dissolved in a mixture of methanol (5 mL) and tetrahydrofuran (5 mL), Raney cobalt (1 g) and 8M ammonia/methanol solution (2 mL) were added to the solution, and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The catalyst was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (118 mg, yield 100%).

1. additionwere added to the solution
2. filtrationThe catalyst was filtered off through celite
3. concentrationthe filtrate was concentrated under reduced pressure

ORD-Eintrag

ord-140a997a8c8e4444ade85b276248a7df

Quelldatensatz

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08247429B2