Butyrohydrazide → HCID 21914092, Verbindung

HRID 887931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 887931
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13](=S)[NH2:14])(=[O:3])[CH3:2].[C:16]([NH:21][NH2:22])(=O)[CH2:17][CH2:18][CH3:19]>C(O)CCC>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13]1[N:14]=[C:16]([CH2:17][CH2:18][CH3:19])[NH:21][N:22]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 77079ButyrohydrazideHCID 219141121-Acetyl-2,3-dihydro-1H-indole-2-carbothioamide

Produkt 1

HCID 21914092HCID 21914092, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A suspension of intermediate (13) (0.0102 mole) in n-butanol (200 ml) was treated with butanoic acid hydrazide (0.0254 mole), stirred for 10 minutes, and then heated to reflux for 10 days. The reaction was cooled, concentrated in vacuo, distributed between DCM and distilled water. The concentrated organic phase was subjected to reverse phase preparatory column chromatography to give 1-acetyl-2,3-dihydro-2-(5-propyl-1H-1,2,4-triazol-3-yl)-1H-indole (compound 91).

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 10 days
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. distillationdistilled water

Quellen und Nachweise

ORD-Eintrag
ord-1af4cf5e9c1e45a485af3af8555c6dd8
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247432B2

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