Chloride → HCID 86621105, Verbindung

HRID 888053Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888053
O[CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1.[Cl-:18]>>[Cl:18][CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 312ChlorideHCID 22340602Butanoic acid, 4-[4-(hydroxymethyl)phenoxy]-, ethyl ester

Produkt 1

HCID 86621105HCID 86621105, Verbindung

Versuchsvorschrift

Ethyl 4-(4-(chloromethyl)phenoxy)butanoate 13i was prepared from 29b according to the protocol described for the compound 13h in Example 26 (Scheme 9). The title chloride 13i was isolated as colorless oil in 96% yield (1.25 g). 1H NMR (400 MHz, CDCl3): δ 1.24 (3H, t, J=7.2 Hz); 2.06 (2H, m); 2.18 (2H, t, J=7.2 Hz)); 4.00 (2H, t, J=6.4 Hz); 4.14 (2H, q, J=7.2 Hz); 4.54 (2H, s); 6.83 (1H, s); 6.86 (1H, s); 7.27 (1H, m); 7.29 (1H, s). MS (ESI): m/z=258.10 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-130013904c5a41fdbaf04d22947d3eb7
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247563B2

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