Trifluoroacetic acid → Trifluoroacetic acid

HRID 888380Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888380
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:21]([O:23][CH3:24])=[O:22])[CH:11]=[C:12]([CH:20]=2)[C:13]([O:15]C(C)(C)C)=[O:14])=[N:6][CH:7]=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[C:27]([OH:29])([C:26]([F:31])([F:30])[F:25])=[O:28].[CH3:24][O:23][C:21]([C:10]1[CH:11]=[C:12]([CH:20]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[CH:9]=1)[C:13]([OH:15])=[O:14])=[O:22]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68499855tert-Butyl methyl 5-(5-methylpyridin-2-yl)isophthalate

Produkt 2

HCID 6422Trifluoroacetic acidHCID 684994173-(Methoxycarbonyl)-5-(5-methylpyridin-2-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl methyl 5-(5-methylpyridin-2-yl)isophthalate in dichloromethane (75 mL) was added 25 mL of trifluoroacetic acid. After 16 h, the reaction was concentrated and dried under vacuum to give TFA salt of the title compound (6.5 g). MS 272.1 (M+1).

Aufarbeitung

  1. concentrationthe reaction was concentrated
  2. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ea1ada1909f640bc8d7b2de2c47a53ca
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247401B2

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