4,4,5,5-Tetramethyl-2-(2-methyl-3-nitrophenyl)-1,3,2-dioxaborolane → 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

HRID 888426

Reaktionsgleichung

Reaktionsgleichung von HRID 888426
[CH3:1][C:2]1([CH3:19])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[C:10]=2[CH3:18])[O:3]1>CO>[CH3:18][C:10]1[C:9]([B:4]2[O:5][C:6]([CH3:7])([CH3:8])[C:2]([CH3:19])([CH3:1])[O:3]2)=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:15]

Komponenten

3

Edukt 1

HCID 467388184,4,5,5-Tetramethyl-2-(2-methyl-3-nitrophenyl)-1,3,2-dioxaborolane

Produkt 1

HCID 467380052-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anilineAusbeute 109 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 500-mL round-bottomed flask equipped with a magnetic stirrer was charged with 4,4,5,5-Tetramethyl-2-(2-methyl-3-nitro-phenyl)-[1,3,2]dioxaborolane (6) (8.44 g; 32.1 mmol) and methanol (150 mL). The reaction flask was twice evacuated and back-filled with argon. 10% Palladium on charcoal (50% wet, 425 mg dry weight) was then added to the solution, and the reaction flask evacuated and back-filled with hydrogen three times. The reaction was then stirred under balloon pressure of hydrogen at room temperature for 13 h. After this time, the flask was twice evacuated and back-filled with argon, then filtered through a pad of Celite 521 and the filtrate concentrated in vacuo. The resulting residue was dried under high vacuum for 1 d to afford a quantitative yield (8.16 g) of 2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine (7) as a white solid: mp 110-112° C.; MS (ESI+) m/z 234 (M+H).

Aufarbeitung

  1. customA 500-mL round-bottomed flask equipped with a magnetic stirrer
  2. customThe reaction flask was twice evacuated
  3. additionback-filled with argon
  4. addition10% Palladium on charcoal (50% wet, 425 mg dry weight) was then added to the solution
  5. customthe reaction flask evacuated
  6. additionback-filled with hydrogen three times
  7. customAfter this time, the flask was twice evacuated
  8. additionback-filled with argon
  9. filtrationfiltered through a pad of Celite 521
  10. concentrationthe filtrate concentrated in vacuo
  11. customThe resulting residue was dried under high vacuum for 1 d

Quellen und Nachweise

ORD-Eintrag
ord-6be12b3ab4e647ef97a067579b932ad3
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247550B2

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