Ethanol → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

HRID 888508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 888508
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:28][CH2:29]O>>[CH2:28]([O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)[CH3:29]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

Produkt 1

HCID 58148866(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

Versuchsvorschrift

To (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 5.4 mmol) in EtOH (30 mL) was added sulfuric acid (1 mL), and the mixture was stirred overnight at room temperature. Once no starting material was seen by analytical LCMS, the reaction was worked up to give (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

Quellen und Nachweise

ORD-Eintrag
ord-dfa3e7d3392747069729aee290d85469
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08247602B2

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