Nitric Acid → 6-Bromo-3,4-difluoro-2-nitrophenol

HRID 889267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889267
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[OH:10].[N+:11]([O-])([OH:13])=[O:12]>S([O-])([O-])(=O)=O.[Ni+].[NH4+].ClCCl>[Br:1][C:2]1[C:3]([OH:10])=[C:4]([N+:11]([O-:13])=[O:12])[C:5]([F:9])=[C:6]([F:8])[CH:7]=1

Komponenten

5

Edukt 2

HCID 944Nitric AcidHCID 27362882-Bromo-4,5-difluorophenol

Produkt 1

HCID 840832366-Bromo-3,4-difluoro-2-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 171000000CID 171000000KatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a round bottom flask containing 2-bromo-4,5-difluorophenol (2.7 g, 12.9 mmol) and ammonium nickel sulfate (2.6 g, 6.46 mmol) is added dichloromethane (15 mL) at RT. A solution of 70% nitric acid (1.2 ml) is added dropwise and the slurry is stirred for 20 to 30 min. The mixture is then quenched with excess MgSO4, filtered and concentrated. The product is used in the next step without purification.

Aufarbeitung

  1. customThe mixture is then quenched with excess MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe product is used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-c98db8f863d24904825e49ce9dc520a8
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252820B2

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