(4-Chlorophenyl)hydrazine → [2-(4-Chloro-phenyl)-2,4,5,6,7,8-hexahydro-cycloheptapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

HRID 889385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889385
[CH2:1]([O:3][C:4](=[O:22])[CH:5]([CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:6](=O)[CH:7]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]1=O)[CH3:2].[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][NH2:31])=[CH:26][CH:25]=1>C(O)C>[CH2:1]([O:3][C:4](=[O:22])[CH:5]([C:6]1[N:30]([C:27]2[CH:28]=[CH:29][C:24]([Cl:23])=[CH:25][CH:26]=2)[N:31]=[C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:7]=12)[CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[CH3:2]

Komponenten

4

Edukt 2

HCID 70624(4-Chlorophenyl)hydrazineHCID 673872822-Cyclohexyl-3-oxo-3-(2-oxo-cycloheptyl)-propionic acid ethyl ester

Produkt 1

HCID 67387348[2-(4-Chloro-phenyl)-2,4,5,6,7,8-hexahydro-cycloheptapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In analogy to the procedure described in example 1.3, 2-cyclohexyl-3-oxo-3-(2-oxo-cycloheptyl)-propionic acid ethyl ester was condensed with (4-chloro-phenyl)-hydrazine (CAS Reg. No. 1073-69-4) in ethanol to give the title compound as orange oil. MS: m/e=415.3 [M+H+].

Quellen und Nachweise

ORD-Eintrag
ord-679dbc9fa00047bf8b77c5298b0ad613
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252826B2

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