Methanol → HCID 178467367, Verbindung

HRID 889526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889526
[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[N:26](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[C:7]2[C:46]([C:50]([O:52][C:53]([O:56][C:57]([O:59][CH2:60][CH2:61][CH:62]([CH3:74])[C@@H:63]([O:70][N+:71]([O-:73])=[O:72])[C@H:64]([O:66][N+:67]([O-:69])=[O:68])[CH3:65])=[O:58])([CH3:55])[CH3:54])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2].CO>C(Cl)Cl>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:23][N:24]=[N:25][N:26]=3)=[CH:14][CH:15]=2)[C:7]2[C:46]([C:50]([O:52][C:53]([O:56][C:57]([O:59][CH2:60][CH2:61][CH:62]([CH3:74])[C@@H:63]([O:70][N+:71]([O-:73])=[O:72])[C@H:64]([O:66][N+:67]([O-:69])=[O:68])[CH3:65])=[O:58])([CH3:54])[CH3:55])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 866470221-[({[(4R,5R)-3-Methyl-4,5-bis(nitrooxy)hexyl]oxy}carbonyl)oxy]-1-methylethyl 2-ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Produkt 1

HCID 178467367HCID 178467367, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-[({[(4R,5R)-3-Methyl-4,5-bis(nitrooxy)hexyl]oxy}carbonyl)oxy]-1-methylethyl 2-ethoxy-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate (1.77 g, 1.76 mmol) was dissolved in CH2Cl2 (5 mL) and MeOH was added (30 mL). After stirring at room temperature for 72 hrs, the solution was concentrated under reduced pressure. The residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2) affording the tile compound as a white solid.

Aufarbeitung

  1. concentrationthe solution was concentrated under reduced pressure
  2. customThe residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2)

Quellen und Nachweise

ORD-Eintrag
ord-66505e7b3df543068af0e120236d3b2a
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252825B2

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