Thionyl Chloride → 3-Cyclopentyl-2-phenylpropionyl chloride

HRID 889600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 889600
[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](O)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:19])=O>CN(C=O)C>[CH:1]1([CH2:6][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([Cl:19])=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 186266423-Cyclopentyl-2-phenylpropanoic acid

Produkt 1

HCID 866254663-Cyclopentyl-2-phenylpropionyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Versuchsvorschrift

To the title B compound, 3-cyclopentyl-2-phenylpropionic acid (3.1 g, 14.2 mmol) is added 10 mL of thionyl chloride and one drop of DMF. The reaction mixture is stirred at ambient temperature for 2 h. The excess thionyl chloride is evaporated and the residue is twice treated with toluene and evaporated to yield 3-cyclopentyl-2-phenylpropionyl chloride as an orange-yellow oil which is selected as such without further purification.

Aufarbeitung

  1. customThe excess thionyl chloride is evaporated
  2. additionthe residue is twice treated with toluene
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-6b5f13eb86734be696b006115b1e12de
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08252931B2

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