Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 889871

Reaktionsgleichung

Reaktionsgleichung von HRID 889871
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C)C=O>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl Chloride2×HCID 27569594-Bromo-2,2-diphenylbutyric acid

Produkt 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

4-Bromo-2,2-diphenylbutyric acid (Compound B(1), 23 g, 72 mmol) was suspended in 150 mL of chloroform, and 20 mL of thionyl chloride (270 mmol) was added dropwise. After addition of the thionyl chloride, 0.2 mL of dimethylformamide was added and the resulting solution heated at reflux for about 4 h. The reaction mixture was then concentrated under reduced pressure to provide 4-bromo-2,2-diphenylbutyric chloride (Compound D(1)) as a pale yellow oil that was used in the following step without further purification.

Aufarbeitung

  1. additionwas added
  2. temperaturethe resulting solution heated
  3. temperatureat reflux for about 4 h
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b0821871a2314e6695b0528c5606f54e
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995168B2

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