4-(Phenoxymethyl)piperidine → 2-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine
Reaktionsgleichung
[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH:12]=[CH2:13])[N:7]=1)([CH3:4])([CH3:3])[CH3:2].[O:14]([CH2:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH2:12][CH2:13][N:25]2[CH2:26][CH2:27][CH:22]([CH2:21][O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:23][CH2:24]2)[N:7]=1)([CH3:4])([CH3:3])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
After dissolving 471 mg of 2-tert-butoxy-6-vinylpyrazine and 505 mg of 4-(phenoxymethyl)piperidine in 10 ml of ethanol, the mixture was stirred for 4 days at 80° C. The reaction solution was concentrated under reduced pressure and the residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain 2-tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine.
Aufarbeitung
- concentrationThe reaction solution was concentrated under reduced pressure
- customthe residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-3172684fb4cc4049a871274b86a5c98c
- Quelldatensatz
- uspto-grants-2006_02
- Patentnummer
- US06995144B2
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