2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 22249950, Verbindung

HRID 890212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 890212
C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N.[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:36][CH3:37])[CH2:34][CH3:35])[CH2:31][CH2:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12>C(Cl)Cl>[Br:15][C:16]1[C:17]2[CH:43]=[CH:42][CH:41]=[CH:40][C:18]=2[O:19][C:20]=1[C:21]1[C:22]([CH3:39])=[N:23][N:24]2[C:29]3[N:30]([CH:33]([CH2:34][CH3:35])[CH2:36][CH3:37])[CH:31]=[CH:32][C:28]=3[C:27]([CH3:38])=[N:26][C:25]=12

Komponenten

4

Edukt 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 22249795HCID 22249795, Verbindung

Produkt 1

HCID 22249950HCID 22249950, VerbindungAusbeute 68,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

DDQ (33 mg, 0.15 mmol) was added to a solution of 3-(3-bromobenzo[b]furan-2-yl)-8-(1-ethylpropyl)-2,5-dimethyl-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine (60 mg, 0.13 mmol) in methylene chloride (10 mL) at room temperature, followed by stirring for one hour. After overnight, the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane), to give the title compound (40 mg) as a reddish brown oil.

Aufarbeitung

  1. waitAfter overnight
  2. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-0294b9c7078e4a1fa7c5f5804ffe0332
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995163B2

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