Potassium Hydroxide → 2-Acetylhexanoic Acid
Reaktionsgleichung
[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([O:7]C)=[O:6])(=[O:3])[CH3:2].[OH-].[K+]>O1CCOCC1>[C:1]([CH:4]([CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([OH:7])=[O:6])(=[O:3])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
3.08 g (17.9 mmol) of methyl 2-acetylhexanoate (Example 14A) is dissolved in 10 ml of dioxane and cooled to 0° C. 7.00 ml of a 3.5 M potassium hydroxide solution are added with cooling. After a reaction time of 5 h, the batch is concentrated, treated with 20 ml of ethyl acetate and 20 ml of water and extracted with shaking. The water phase is recovered, cooled to 0° C. and slowly treated with 1 N hydrochloric acid until a pH of 1 is reached. The mixture is then extracted with dichloromethane. The dichloromethane phase is dried and directly reacted further without concentrating.