Methanesulfonate → 7-(N-benzylmorpholin-2-ylmethoxy)-4-(2-bromo-4-fluorophenoxy)-6-methoxyquinazoline

HRID 890967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 890967
S([O-])(=O)(=O)C.[CH2:6]([N:13]1[CH2:18][CH2:17][O:16][CH:15]([CH2:19][OH:20])[CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[Br:21][C:22]1[CH:41]=[C:40]([F:42])[CH:39]=[CH:38][C:23]=1[O:24][C:25]1[C:34]2[C:29](=[CH:30][C:31](O)=[C:32]([O:35][CH3:36])[CH:33]=2)[N:28]=[CH:27][N:26]=1>>[CH2:6]([N:13]1[CH2:18][CH2:17][O:16][CH:15]([CH2:19][O:20][C:31]2[CH:30]=[C:29]3[C:34]([C:25]([O:24][C:23]4[CH:38]=[CH:39][C:40]([F:42])=[CH:41][C:22]=4[Br:21])=[N:26][CH:27]=[N:28]3)=[CH:33][C:32]=2[O:35][CH3:36])[CH2:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Komponenten

4

Edukt 3

HCID 85257MethanesulfonateHCID 2776358(4-Benzylmorpholin-2-yl)methanolHCID 1356979064-(2-Bromo-4-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline

Produkt 1

HCID 222438087-(N-benzylmorpholin-2-ylmethoxy)-4-(2-bromo-4-fluorophenoxy)-6-methoxyquinazoline

Versuchsvorschrift

Using an analogous procedure to that described in the first paragraph of the portion of Note [140] immediately above which is concerned with the preparation of starting materials, the mesylate of N-benzylmorpholin-2-ylmethanol (Synth. Commun. 1980, 10, 59–73) was reacted with 4-(2-bromo-4-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline (4.56 g) to give 7-(N-benzylmorpholin-2-ylmethoxy)-4-(2-bromo-4-fluorophenoxy)-6-methoxyquinazoline; Mass Spectrum: M+H+ 554 and 556.

Aufarbeitung

  1. customis concerned with the preparation of starting materials

Quellen und Nachweise

ORD-Eintrag
ord-ba148dcc906a4eacb0b2e3606d0d4477
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07001904B1

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