3-Chlorobenzenesulfonamide → N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-3-chlorobenzenesulfonamide

HRID 891099

Reaktionsgleichung

Reaktionsgleichung von HRID 891099
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[Cl:32][C:33]1[CH:34]=[C:35]([S:39]([NH2:42])(=[O:41])=[O:40])[CH:36]=[CH:37][CH:38]=1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:42][S:39]([C:35]3[CH:36]=[CH:37][CH:38]=[C:33]([Cl:32])[CH:34]=3)(=[O:41])=[O:40])=[O:24])=[CH:16][CH:15]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 5193773-ChlorobenzenesulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Produkt 1

HCID 22244602N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-3-chlorobenzenesulfonamide

Versuchsvorschrift

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 3-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 7.91-7.90 (1H, m), 7.83-7.79 (1H, m), 7.53-7.20 (11H, m), 6.32 (1H, br.s), 3.47-3.40 (2H, m), 2.81 (2H, t, J=6.6 Hz), 2.30 (3H, s), 2.22 (3H, s).

Quellen und Nachweise

ORD-Eintrag
ord-320dec2d673e44ff8215718c4d713950
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07001917B2

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