Trifluoroacetic acid → isoquinoline-1-carboxylic acid {1-[(2-hydroxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide

HRID 891192Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 891192
C([O:3][CH:4]1[CH:8]([NH:9][C:10]([CH2:12][N:13]2[CH2:19][CH:18]=[CH:17][CH2:16][CH:15]([NH:20][C:21]([C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=[CH:25][N:24]=3)=[O:22])[C:14]2=[O:33])=[O:11])[CH2:7][C:6](=[O:34])[O:5]1)C.FC(F)(F)C(O)=O>CC#N.O>[OH:3][CH:4]1[CH:8]([NH:9][C:10]([CH2:12][N:13]2[CH2:19][CH:18]=[CH:17][CH2:16][CH:15]([NH:20][C:21]([C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=[CH:25][N:24]=3)=[O:22])[C:14]2=[O:33])=[O:11])[CH2:7][C:6](=[O:34])[O:5]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86590750isoquinoline-1-carboxylic acid {1-[(2-ethoxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide

Produkt 1

HCID 75025996isoquinoline-1-carboxylic acid {1-[(2-hydroxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 18373917Acetonitrile--water (1/1)Lösungsmittel

Versuchsvorschrift

To a solution of isoquinoline-1-carboxylic acid {1-[(2-ethoxy-5-oxo-tetra-hydrofuran-3-ylcarbamoyl)methyl]-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl} amide, 6, from above in CH3CN/H2O is added trifluoroacetic acid. After stirring for 30 minutes the solution is concentrated in vacuo and the crude product purified by preparative reverse phase HPLC to afford the desired product.

Aufarbeitung

  1. concentrationis concentrated in vacuo
  2. customthe crude product purified by preparative reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-460d2057d4e04209a19a070ff7e863c1
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07001899B2

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