p-Toluenesulfonic acid monohydrate → 3-(2-Quinolin-2-yl-vinyl)-phenol

HRID 892143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 892143
COCCOC[O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:9]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([OH:7])[CH:13]=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 544075821-(2-Methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene

Produkt 1

HCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of 1-(2-methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene (120 mg, 0.35 mmol, example 16) is added p-toluene sulphonic acid monohydrate. (74 mg, 0.39 mmol). The resulting solution is heated to 60° C. and stirred at this temperature for 4 h. The reaction mixture is then cooled, concentrated and the residue taken up in dichloromethane. This solution is washed with sat. NaHCO3 solution, dried over MgSO4 then concentrated to give the title compound as a solid. MS (ESI) 248 (M+H)+.

Aufarbeitung

  1. temperatureThe reaction mixture is then cooled
  2. concentrationconcentrated
  3. washThis solution is washed with sat. NaHCO3 solution
  4. dry with materialdried over MgSO4
  5. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-9e6fd853a2dc49e28aaf2c784df32eee
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07005440B1

Notizen zur Reaktion

Wird geladen…