Propylamine → HCID 135537129, Verbindung

HRID 892436Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 892436
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

Komponenten

4

Edukt 2

HCID 7852PropylamineHCID 178458304HCID 178458304, Verbindung

Produkt 1

HCID 135537129HCID 135537129, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to lo yield an oil which solidified on washing with water. The residue was recrystallised from isopropanol: water to yield the title compound, 0.56 g, m.p. 172°-3° C.

Aufarbeitung

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto lo yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallised from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-e0be2acdc011471a9a345b38f6d44286
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05118686

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