Potassium Hydroxide → 99517-24-5

HRID 893713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 893713
[C:1]([C:5]1[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=[C:7]([Cl:14])[CH:6]=1)([O:3]C)=[O:2].[OH-].[K+]>CO>[Cl:14][C:7]1[CH:6]=[C:5]([C:1]([OH:3])=[O:2])[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 14838646HCID 14838646, Verbindung

Produkt 1

HCID 1483864799517-24-5Ausbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 7-carbomethoxy-5-chlorobenzo[b]furan (6c) (3.02 g, 14.3 mmol) containing potassium hydroxide (3.22 g) in 100 ml of aqueous methanol (CH3OH/H2O=3/2) was stirred at room temperature overnight. The mixture was concentrated under reduced pressure The residue was acidified with conc. HCl to pH of about 1, cooled in freezer for several hours and filtered to give 7c as an off-white solid (2.65 g, 94.3%), mp 212°-215° C. NMR (DMSO-d6) δ 8.0-6.87 (m, 5H, aromatic protons and OH).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure The residue
  2. temperaturecooled in freezer for several hours
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-2aa7ddf1962d414a9bbb4f4355653206
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05126364

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