Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate → 5-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

HRID 894059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 894059
[C:1]1([C:7]2[CH:24]=[CH:23][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([O:20]CC)=[O:19])[CH:14]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([C:13]3[NH:17][CH:16]=[C:15]([C:18]([OH:20])=[O:19])[CH:14]=3)=[O:12])=[CH:23][CH:24]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 1

HCID 12897070Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate

Produkt 1

HCID 128970715-(4-Phenylbenzoyl)pyrrole-3-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Ethyl 5-(4-phenylbenzoyl)pyrrole-3-carboxylate (3.1 g.) was boiled in an open flask with 100 ml. of methanol and 70 ml. of 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation. The solution was cooled to room temperature, and product which had precipitated as the sodium salt recovered by filtration. The salt was stirred with 75 ml. of 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration.

Aufarbeitung

  1. customof 1 N sodium hydroxide for 1 hour by which time most of the methanol was removed by evaporation
  2. customproduct which had precipitated as the sodium salt
  3. filtrationrecovered by filtration
  4. filtrationof 1 N hydrochloric acid and 5-(4-phenylbenzoyl)pyrrole-3-carboxylic acid (1 g., m.p. >280° C.) recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-d2117a4c493c4680aa887f087e4b7233
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04282242

Notizen zur Reaktion

Wird geladen…