Sodium Hydroxide → HCID 12897098, Verbindung

HRID 894075Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 894075
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([O:14]CCO)=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 20400896HCID 20400896, Verbindung

Produkt 1

HCID 12897098HCID 12897098, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-Hydroxyethyl 4-(4-chlorophenoxy)pyrrole-2-carboxylate (400 mg.) was dissolved in 10 ml. of acetone and 10 ml. of 1 N sodium hydroxide and left to stand at room temperature for approximately 16 hours. Acetone was evaporated in vacuo, the aqueous residue was acidified with conc. hydrochloric acid and crystalline product (320 mg.) recovered by filtration. Recrystallization from ether/hexane of 400 mg. of product prepared in this manner affored purified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237).

Aufarbeitung

  1. customAcetone was evaporated in vacuo
  2. filtrationrecovered by filtration
  3. customRecrystallization from ether/hexane of 400 mg
  4. customof product prepared in this manner
  5. customaffored purified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237)

Quellen und Nachweise

ORD-Eintrag
ord-0bdaf2120b124ea68825874d411c3937
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04282242

Notizen zur Reaktion

Wird geladen…