HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 895991Erstellt: 26. Oktober 2026
Diisopropylethylamine → Diethyl 5-(4-fluorophenyl)-2-furanphosphonate
https://huagongshe.com/reaction/895991
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Edukt | Diethyl 5-iodo-2-furanphosphonate | HCID 22280644 | — |
| Katalysator | Bis(acetonitrile)dichloropalladium | HCID 6093782 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | Diethyl 5-(4-fluorophenyl)-2-furanphosphonate | HCID 22349233 | — |
Reaktionsschritte
A mixture of diethyl 5-iodo-2-furanphosphonate (1 mmol), 4-fluorophenylboronic acid (2 mmol), diisopropylethylamine (DIEA) (4 mmol) and bis(acetonitrile)dichloropalladium(II) (0.05 mmol) in 6 mL DMF was heated at 75° C. for 16 h. Extraction and chromatography provided diethyl 5-(4-fluorophenyl)-2-furanphosphonate as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06919322B2 |
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| Quelldatensatz | uspto-grants-2005_07 |
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| ORD ID | ord-cea20ef400b64a899f717c7737dd3f75 |
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| Quellennotiz | uspto-grants-2005_07 |
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