Thionyl Chloride → HCID 22349860, Verbindung

Reaktionsgleichung

[C:1]([C:5]1[N:10]=[C:9](O)[CH:8]=[C:7]([CH:12]([F:14])[F:13])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:17])=O.C(=O)(O)[O-].[Na+]>ClCCl>[C:1]([C:5]1[N:10]=[C:9]([Cl:17])[CH:8]=[C:7]([CH:12]([F:14])[F:13])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

Versuchsvorschrift

2.8 g of 2-tert-butyl-4-hydroxy-6-difluoromethyl-pyrimidine (13.9 mmol) and 3 ml of thionylchloride were stirred 14 h at room temperature and an additional 3 h at 76° C. 20 ml of dichloromethane were added with cooling, followed by addition of 15 ml of a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, dried over magnesium sulfate and the solvent was evaporated to yield the crude title compound which was purified by column chromatography on silica gel (dichloromethane/hexane 1:1) to yield 0.8 g of product.