(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester → HCID 10464546, Verbindung

HRID 897165Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 897165
C([O:8][C:9](=[O:17])[C@@:10]1([C:13]([F:16])([F:15])[F:14])[O:12][CH2:11]1)C1C=CC=CC=1.[H][H]>[Pt]=O.CO>[O:12]1[CH2:11][C@@:10]1([C:13]([F:16])([F:15])[F:14])[C:9]([OH:17])=[O:8]

Komponenten

5

Edukt 2

HCID 10014785(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 10464546HCID 10464546, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Into a 500 ml three-necked round-bottomed flask equipped with a stirrer, (S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester (20.9 g, 84.9 mmol, 99 ee %) was charged, and 180 ml of methanol was added for dissolution. Platinum oxide (1.63 g) was added, and then, the reaction system was substituted by hydrogen. After stirring at room temperature for 4 hours, platinum oxide was filtered off. The solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g) was obtained (yield: 90%).

Aufarbeitung

  1. customInto a 500 ml three-necked round-bottomed flask equipped with a stirrer
  2. filtrationplatinum oxide was filtered off
  3. distillationThe solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g)
  4. customwas obtained (yield: 90%)

Quellen und Nachweise

ORD-Eintrag
ord-ee5de33be4fd47aa995c76b52ed103ef
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06921832B2

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