(3R)-3-Ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one → (3R)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-])=O)=[C:6]([NH:8][C@H:9]([CH2:13][CH3:14])[C:10](O)=[O:11])[CH:7]=1.C([C@H]1NC2C(=CC(F)=CC=2)NC1=O)C>>[CH2:13]([C@H:9]1[NH:8][C:6]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:7]=2)[NH:15][C:10]1=[O:11])[CH3:14]Komponenten
3
Versuchsvorschrift
(2R)-2-(5-Fluoro-2-nitrophenylamino)-butyric acid was treated according to the procedure for the preparation of (3R)-3-ethyl-7-fluoro-3,4-dihydroquinoxalin-2(1H)-one (see Example 1) to yield (3R)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one (54%). MS (ESI) m/z 195 ([M+H]+); HRMS: calcd for C10H11FN2O, 194.08558; found (ESI_FT), 195.08807; Anal. Calcd for C10H11FN2O: C, 61.85; H, 5.71; N, 14.42. Found: C, 61.77; H, 5.76; N, 14.33.