Potassium Carbonate → 1-(2-Chloro-4-nitro-benzyl)-pyrrolidine

HRID 898586Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 898586
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[Cl:18].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C.ClCCl>[Cl:18][C:10]1[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=1[CH2:8][N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 30163681-(Bromomethyl)-2-chloro-4-nitrobenzene

Produkt 1

HCID 576632361-(2-Chloro-4-nitro-benzyl)-pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10.50 g (74.452 mmol) potassium carbonate was added to a solution of 7.400 g (29.543 mmol) of 1-bromomethyl-2-chloro-4-nitro-benzene and 5.00 mL (59.300 mmol) pyrrolidine in 150 mL acetonitrile and the mixture was stirred for 16 h at RT. The reaction mixture was diluted with 200 mL dichloromethane, filtered and the filtrate evaporated down i. vac. The residue was taken up in EtOAc, the org. phase was washed with water, dried over magnesium sulphate and evaporated down i. vac. The crude product was used in the next reaction step without any further purification.

Aufarbeitung

  1. filtrationfiltered
  2. customthe filtrate evaporated down i
  3. washphase was washed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated down i
  6. customThe crude product was used in the next reaction step without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-c84acf0f55b54d35ba4b0b73163d9c1b
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351719B2

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