3-(Pyridin-2-yl)prop-2-enoic acid → HCID 59691598, Verbindung
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1/[CH:7]=[CH:8]/[C:9]([OH:11])=O.[Cl:12][C:13]1[CH:14]=[C:15]([NH2:27])[CH:16]=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24]>>[Cl:12][C:13]1[CH:14]=[C:15]([NH:27][C:9](=[O:11])/[CH:8]=[CH:7]/[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24]Komponenten
3
Versuchsvorschrift
Prepared analogously to Example 172 starting from (E)-3-pyridin-2-yl-acrylic acid and 3-chloro-4-(2-diethylamino-ethoxy)-phenylamine (Z2b) at RT (72 h). The crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1) and recrystallisation from petroleum ether.
Aufarbeitung
- customThe crude product was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:0.1) and recrystallisation from petroleum ether