Potassium Carbonate → HCID 59692072, Verbindung

HRID 898674Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 898674
C[Si](C#CC1C=C2C(=CC=1)OC(C)(C)CC2(C)C)(C)C.C[Si]([C:25]#[C:26][C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])(C)C.C(=O)([O-])[O-].[K+].[K+]>CO>[C:26]([C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])#[CH:25]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 596920816-Trimethlsilanylethynyl-2,2,4,4-tetramethyl chroman-8-carbaldehydeHCID 69216465trimethyl-[2-(2,2,4,4-tetramethyl-3H-chromen-6-yl)ethynyl]silane

Produkt 1

HCID 59692072HCID 59692072, VerbindungAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Compound 43, 1.78 g, 5.4 mmol) in methanol (20 mL) was treated with potassium carbonate (0.745 g, 5.4 mmol) and the resulting reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was filtered, the filtrate was evaporated in vacuo and the residue was subjected to flash column chromatography over silica gel (230-400 mesh) using 2-5% ethyl acetate in hexane as the eluent to afford the title compound (1.1 g, 85%).

Aufarbeitung

  1. customthe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b987f7c7be584d95a9cc8e28a92f5996
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351737B2

Notizen zur Reaktion

Wird geladen…