Perindopril Erbumine → Perindopril erbumine monohydrate

HRID 898743

Reaktionsgleichung

Reaktionsgleichung von HRID 898743
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:6]

Komponenten

3

Edukt 1

HCID 441313Perindopril Erbumine

Produkt 1

HCID 9847044Perindopril erbumine monohydrateAusbeute 163,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Perindopril erbumine (20 gms) was suspended in ethyl acetate (300 ml). The contents were heated to dissolve the solids and cooled to 10 EC. The resulting slurry was filtered and dried in air having a relative humidity of at least 75% to give perindopril erbumine monohydrate (17 gms).

Aufarbeitung

  1. temperatureThe contents were heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 10 EC
  4. filtrationThe resulting slurry was filtered
  5. customdried in air

Quellen und Nachweise

ORD-Eintrag
ord-a699c9ecef724a7c98932c97321fce17
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351840B2

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